The CKMS study is a multi-centre, prospective registry being conducted across leading tertiary care institutions in India to systematically capture real-world data on cardiovascular, kidney, and metabolic diseases. The study is designed to evaluate disease staging and progression over a total duration of 18 months.

Participant recruitment will be undertaken over a 6-month period, with a target sample size of 2250 individuals across all participating sites. Following enrolment, comprehensive baseline assessments will be conducted, including socio-demographic characteristics, clinical history, lifestyle factors, treatment patterns, clinical measurements, and relevant laboratory investigations.

Participants will be followed up at 6 and 12 months post-enrolment to assess disease progression, treatment modifications, and clinical outcomes. The registry also incorporates information on physical activity, mental health, and quality of life to enable a more holistic understanding of disease burden.

Standardised case record forms and a secure electronic data capture system are used to ensure uniform and consistent data collection across all sites. Ongoing data monitoring and coordination with participating centres help maintain data quality and completeness.

The multi-centre design enables comparison across regions and populations, providing robust evidence on the continuum and overlap of cardiometabolic diseases in the Indian population.